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Saturday, July 18, 2020 | History

6 edition of Physical methods to characterize pharmaceutical proteins found in the catalog.

Physical methods to characterize pharmaceutical proteins

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Published by Plenum Press in New York .
Written in English

    Subjects:
  • Protein drugs -- Analysis,
  • Proteins -- chemistry,
  • Molecular Structure,
  • Chemistry, Pharmaceutical -- methods,
  • Biopharmaceutics -- methods

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by James N. Herron, Wim Jiskoot, and Daan J.A. Crommelin.
    SeriesPharmaceutical biotechnology ;, v. 7
    ContributionsHerron, James N., Jiskoot, Wim., Crommelin, D. J. A.
    Classifications
    LC ClassificationsRS431.P75 P47 1995
    The Physical Object
    Paginationxvii, 362 p. :
    Number of Pages362
    ID Numbers
    Open LibraryOL801283M
    ISBN 100306450267
    LC Control Number95037641

      The LibreTexts libraries are Powered by MindTouch ® and are supported by the Department of Education Open Textbook Pilot Project, the UC Davis Office of the Provost, the UC Davis Library, the California State University Affordable Learning Solutions Program, and Merlot. We also acknowledge previous National Science Foundation support under grant numbers . Thiols and disulfides of proteins and low-molecular-weight compounds, such as glutathione, are involved in many essential cellular functions and reliable and accurate methods to identify and.

    Chemical and Physical Characterization of Therapeutic Proteins in Solution and Amorphous Solids By Sandipan Sinha B.S. Pharmaceutical Technology, Jadavpur University, M.S. Industrial Pharmacy, the University of Toledo, M.S. Pharmaceutical Chemistry, the University of Kansas, Biophysical Characterization of Proteins in Developing Biopharmaceuticals is concerned with the analysis and characterization of the higher-order structure (HOS) or conformation of protein based drugs. Starting from the very basics of protein structure this book takes the reader on a journey on how to best achieve this goal using the key relevant and practical methods commonly .

    Protein methods are the techniques used to study are experimental methods for studying proteins (e.g., for detecting proteins, for isolating and purifying proteins, and for characterizing the structure and function of proteins, often requiring that the protein first be purified).Computational methods typically use computer programs to analyze proteins. the biotechnology and pharmaceutical industry to date detectable but impossible to characterize by physical methods in the amounts typically loaded onto a gel sufficient to characterize proteins from completely sequenced genomes such as ye as the masses of all.


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Physical methods to characterize pharmaceutical proteins Download PDF EPUB FB2

Proteins are different from "traditional" low-molecular-weight drugs. As a group, they exhibit a number of biopharmaceutical and formulation problems. These problems have drawn considerable interest from both industrial and aca­ demic environments, forcing pharmaceutical scientists to explore a domain previ­ ously examined only by peptide and.

Proteins are still gaining importance in the pharmaceutical world, where they are used to improve our arsenal of therapeutic drugs and vaccines and as diagnostic tools. Proteins are different from "traditional" low-molecular-weight drugs.

As a group, they exhibit a. Proteins are still gaining importance in the pharmaceutical world, where they are used to improve our arsenal of therapeutic drugs and vaccines and as diagnostic tools. Proteins are different from "traditional" low-molecular-weight drugs. As a group, they exhibit a number of biopharmaceutical and formulation : Hardcover.

ISBN: OCLC Number: Description: xvii, pages: illustrations ; 24 cm: Contents: Ch. Application of Fluorescence Spectroscopy for Determining the Structure and Function of Proteins / Wim Jiskoot, Vladimir Hlady, John J.

Naleway and James N. Herron --Ch. ural Information on Proteins from Circular Dichroism Spectroscopy:. Find many great new & used options and get the best deals for Pharmaceutical Biotechnology: Physical Methods to Characterize Pharmaceutical Proteins 7 (, Hardcover) at the best online prices at eBay.

Free shipping for many products. Get this from a library. Physical methods to characterize pharmaceutical proteins. [James N Herron; Wim Jiskoot; D J A Crommelin;] -- This collection of state-of-the-art research describes the most frequently used techniques for structural analysis of proteins.

Chapters focus on the impressive progress that has been made in the. Proteins are still gaining importance in the pharmaceutical world, where they are used to improve our arsenal of therapeutic drugs and vaccines and as diagnostic tools.

Proteins are different from "traditional" low-molecular-weight drugs. As a group, they exhibit a number of biopharmaceutical and formulation problems. These problems have drawn considerable. Physical Methods to Characterize Pharmaceutical Proteins by James N Herron (Editor), Wim Jiskoot (Editor), Daan J A Crommelin (Editor) starting at $ Physical Methods to Characterize Pharmaceutical Proteins has 2 available editions to buy at Half Price Books Marketplace.

Discover Book Depository's huge selection of Jiskoot Wim books online. Free delivery worldwide on over 20 million titles. Discover Book Depository's huge selection of James N Herron books online. Free delivery worldwide on over 20 million titles.

Biophysical Characterization of Proteins in Developing Biopharmaceuticals is concerned with the analysis and characterization of the higher-order structure (HOS) or conformation of protein based drugs. Starting from the very basics of protein structure this book takes the reader on a journey on how to best achieve this goal using the key.

Complexation, a term with a broad definition, is used in the context of this chapter to characterize the covalent or noncovalent interactions between two or more compounds that are capable of independent existence. 1 The ligand is a molecule that interacts with another molecule, the substrate, to form a molecules can form complexes with other small molecules.

A protein must be purified before its structure and the mechanism of its action can be studied. However, because proteins vary in size, charge, and water solubility, no single method can be used to isolate all proteins.

To isolate one particular protein from the estima different proteins in a cell is a daunting task that requires methods both for separating proteins and for Cited by: 1.

Although this series no longer publishes new content, the published titles listed below may be still available on-line (e. via the Springer Book Archives) and in print. The improvements in the Chromatographic analysis of proteins and peptides during the last decade contributed significantly to the development of (recombi-nant) pharmaceutical proteins.

The availability of these analytical methods for the characterization and purity determination of proteins enabled the improvement of the overall manufacturing Cited by: 5. In the Structural Genomics Consortium (SGC, ), we have established a high throughput platform using a well format to characterize human proteins that includes screening the proteins against a variety of chemical series and focused chemical libraries, as well as investigating their binding and catalytic by: hub proteins: Most proteins interact with only a few other proteins while a small number of proteins (hubs) have many interaction partners.

Hub proteins and non-hub proteins differ in several respects; however, understanding is not complete about what properties characterize the hubs and set them apart from proteins of low connectivity.

This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles, and discusses regulatory requirements.

Analytical methods covered in the book include separation, light scattering. • Current computational as well as experimental methods for studying proteins, plus key databases of structural and functional information.

• The theory behind our understanding of the forces and energetics underlying protein folding, stability, dynamics, ligand selectivity, and catalysis, explained in an intuitive but rigorous way.

The quality and performance tests used to characterize pharmaceutical aerosol drug products fall generally into physicochemical characterization and aerosol performance methods. Because the scientific principles on which these methods are based are not subject to change, very little technical development can be expected.

7 Calorimetric Methods to Characterize the Forces Driving Macromolecular Association and Folding Processes Conceic¸ ˜ao A.S.A. Minetti, Peter L.

Privalov, and David P. Remeta. 8 Virtual Ligand Screening Against Comparative Models of Proteins Hao Fan. 9 Atomistic and Coarse-Grained Molecular Dynamics Simulations of Membrane Proteins Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition discusses the development of therapeutic peptides and proteins, from the production of active compounds via basic pre-formulation and formulation to the registration of the final product.

Providing integrated solutions, this book discusses.Genome sequencing provides a wealth of information on predicted gene products (mostly proteins), but the majority of these have no known function.

Two-dimensional gel electrophoresis and mass spectrometry have, coupled with searches in protein and EST databases, transformed the protein-identification process. The proteome is the expressed protein complement of a Cited by: